Delta Sleep-Inducing Peptide (DSIP) is a neuropeptide found in various parts of the body, including plasma, peripheral organs, and neurons. It is known for its ability to promote delta wave sleep in mammals and can easily cross the blood-brain barrier, as well as be absorbed through the digestive system. Research has indicated a correlation between DSIP levels in plasma and the circadian rhythm, with concentrations rising in connection with the onset of sleep. Additionally, DSIP has been shown to influence hormone levels, neurotransmitter activity, and overall cognitive function. In individuals suffering from schizophrenia and depression, studies have revealed lower DSIP levels in cerebrospinal fluid and plasma compared to healthy individuals. Clinically, DSIP has been employed in the treatment of opioid and alcohol withdrawal, helping to alleviate symptoms experienced by patients during detoxification.